By Katabarwa Albert

What is tuberculosis?

Tuberculosis (TB) is a multisystemic infectious disease caused by Mycobacterium tuberculosis (or TB), a rod-shaped bacterium. TB (TB may stand for the disease or the bacteria that cause the disease) is the most common cause of infectious disease-related mortality worldwide (about 10 million people worldwide were sick with TB in 2017, and about 1.7 million people died from TB worldwide in 2017 according to the World Health Organization [WHO]). HIV-associated TB infections are a leading cause of death in HIV patients.

TB symptoms can span such a wide range that TB is termed the “great imitator” by many who study infectious diseases because TB symptoms can mimic many different diseases. Additional terms are used to describe TB. The terms include consumption, Pott’s disease, active, latent, pulmonary, cutaneous, and others (see the following section), and they appear in both medical and nonmedical publications.

In most instances, the different terms refer to a specific type of TB with some unique symptoms or findings. The most common site (about 85%) for TB to develop is in the pulmonary tract. Humans are the only known hosts for Mycobacterium tuberculosis (although animals can get infected).

There is a vast amount of detailed information available in the medical literature on all aspects of this potentially debilitating and lethal disease. The goal of this article is to introduce the reader to TB and help them to obtain a general knowledge about TB’s cause, transmission, diagnostic tests, treatments, and prevention methods.

Are there different types of tuberculosis (TB)?

There are many types of tuberculosis, but the main two types are termed either active or latent tuberculosis infection. Active TB is when the disease is actively producing symptoms and can be transmitted to other people; latent disease is when the person is infected with Mycobacterium tuberculosis bacteria, but the bacteria are not producing symptoms (usually due to the body’s immune system suppressing the bacterial growth and spread) and have no TB bacteria in the sputum.

People with latent TB usually cannot transfer Mycobacterium tuberculosis bacteria to others unless the immune system fails; the failure causes reactivation (bacterial growth is no longer suppressed) that results in active TB so the person becomes contagious. Latent TB resembles chickenpox infection that goes dormant and may reactivate years later.

Many other types of TB exist in either the active or latent form. These types are named for the signs and for the body systems Mycobacterium tuberculosis preferentially infect, and these infection types vary from person to person.

Consequently, pulmonary tuberculosis mainly infects the pulmonary system, cutaneous TB has skin symptoms, while miliary TB describes widespread small infected sites (lesions or granulomas about 1 mm-5 mm) found throughout body organs. It is not uncommon for some people to develop more than one type of active TB. More types will be listed in the symptoms and signs section below.

Atypical mycobacteria that may cause disease are the M. avium complex, M. fortuitum complex, and M. kansasii.

What causes tuberculosis?

The cause of TB is infection of human tissue(s) by the bacterium Mycobacterium tuberculosis (mycobacteria or TB). These bacteria are slow growing, aerobic, and can grow within body cells (an intracellular parasitic bacterium). Its unique cell wall helps protect it from the body’s defenses and gives mycobacteria the ability to retain certain dyes like fuchsin (a reddish dye) after an acid rinse that rarely happens with other bacterial, fungal, or parasitic genera.

Mycobacteria that escape destruction by body defenses may be spread by blood or lymphatic pathways to most organs, with preference to those that oxygenate well (lungs, kidneys, and bones, for example). Typical TB lesions, termed granulomas, usually consist of a central necrotic area, then a zone with macrophages, giant Langerhans cells and lymphocytes that become surrounded by immature macrophages, plasma cells, and more lymphocytes.

What are risk factors for tuberculosis?

Although TB is not easily spread, it is usually spread between people who are in close contact (working together or living together).

There are many risk factors for developing tuberculosis. Certain groups of people have a high risk, such as people who work in hospitals and other areas where TB-infected people may reside (jails, nursing homes, group homes for HIV patients, homeless shelters). Close association with drug users, or people with known TB infections are also at higher risk. Other people at high risk include the following:

1.Visitors and immigrants from areas known to have high incidence of TB
2.Children and the elderly with weakened immune systems (especially those with a positive TB skin test, see below)
3.Patients with HIV infection
4.Drug abusers, especially IV drug abuse
5.Head and neck cancer patients
6.Transplant patients
7.Diabetics
8.Kidney disease patients
9.People undergoing immunosuppressive therapy
10.Silicosis.

What are tuberculosis symptoms and signs?

Although there are a number of TB types, pulmonary tuberculosis is responsible for the majority (about 85%) of TB infections. Consequently, pulmonary TB symptoms and signs may occur with or even before other types of TB are diagnosed. The classical clinical symptoms and signs of pulmonary TB may include the following:

1.Fever
2.Night sweats
3.Cough (often chronic)
4.Hemoptysis (coughing up bloody sputum)
5.Decrease or loss of appetite
6.Weight loss and/or muscle loss (unintentional)
7.Fatigue and/or malaise
8.Chest pain (pain while breathing)
9.Shortness of breath
10.Swollen lymph nodes
11.Pneumonitis (may be the only symptom in the elderly).

Other types are loosely classified as extra pulmonary and often have symptoms that are nonspecific but frequently localized to the involved site. The following includes the signs and symptoms of additional types of TB:

1.Skeletal TB (also termed Pott’s disease): spinal pain, back stiffness, paralysis is possible
2.TB meningitis: headaches (variable in length but persistent), mental changes, coma
3.TB arthritis: usually pain in a single joint (hips and knees most common)
4.Genitourinary TB: dysuria, flank pain, increased frequency, masses or lumps (granulomas)
5.Gastrointestinal TB: difficulty swallowing, nonhealing ulcers, abdominal pain, malabsorption, diarrhea (may be bloody)
6.Miliary TB: many small nodules widespread in organs that resemble millet seeds.

Is TB contagious, and how long is the incubation period and contagious period?

TB is contagious and can be spread to others by airborne droplets during sneezing, coughing, and contact with sputum, so you can get the disease by close contact with infected people; outbreaks occur in crowded conditions. The incubation period may vary from about two to 12 weeks. A person may remain contagious for a long time (as long as viable TB bacteria are present in sputum) and can remain contagious until they have been on appropriate therapy for several weeks. However, some people may be infected but suppress the infection and develop symptoms years later; some never develop symptoms or become contagious.

How do physicians diagnose tuberculosis? What is involved with TB testing?

Because TB may occur as either a latent or active form, the definitive diagnosis of active tuberculosis depends on the culture of mycobacteria from sputum or tissue biopsy.

However, it may take weeks for these slow-growing bacteria to grow on specialized media. Since patients with latent TB do not require isolation or immediate drug therapy, it is useful to determine if a person is either not infected, has a latent infection, or is actively infected with transmissible TB bacteria. Consequently, doctors needed a presumptive test(s) that could reasonably assure that the person was infected or not so therapy could begin.

After getting a patient’s history and physical exam data, the next usual test is the skin test (termed the Mantoux tuberculin skin test or the tuberculin skin test or TST). The test involves injecting tuberculin (an extract made from killed mycobacteria) into the skin.

In about 48-72 hours, the skin is examined for induration (swelling) by a qualified person; a positive test (induration) strongly suggests the patient has either been exposed to live mycobacteria or is actively infected (or had been vaccinated); no induration suggests the person tests negative for TB. This test can have false-positive results (especially in individuals vaccinated for TB with the BCG vaccine). False negative results can be caused by patients who are immunocompromised.

What is the treatment for tuberculosis?

The treatment for TB depends on the type of TB infection and drug sensitivity of the mycobacteria. For latent TB, three anti-TB drugs are used in four different recommended schedules. The drugs are isoniazid (INH), rifampin (RIF; Rifadin), and rifapentine (RPT; Priftin) and the CDC’s four recommended schedules are below and are chosen by the treating doctor based on the patients overall health and type of TB the patient was likely exposed to.

Drugs Duration Interval Minimum Doses
Isoniazid 9 months Daily
Twice weekly 270
76
Isoniazid 6 months Daily
Twice weekly 180
52
Isoniazid and Rifapentine 3 months Once weekly 12
Rifampin 4 months Daily 120
Table reproduced and modified from the MoH;

First-line drugs used to treat active TB are INH, RIF, ethambutol (EMB; Myambutol), and pyrazinamide. The CDC offers a guide for the basic treatment schedules for active TB (drug-susceptible TB organisms) as follows:

Preferred Regimen Alternative Regimen Alternative Regimen
Initial Phase
Daily INH, RIF, PZA, and EMB* for 56 doses (8 weeks) Initial Phase
Daily INH, RIF, PZA, and EMB* for 14 doses (2 weeks), then twice weekly for 12 doses (6 weeks) Initial Phase
Thrice-weekly INH, RIF, PZA, and EMB* for 24 doses (8 weeks)
Continuation Phase
Daily INH and RIF for 126 doses (18 weeks)
or
twice-weekly INH and RIF for 36 doses (18 weeks) Continuation Phase
Twice-weekly INH and RIF for 36 doses (18 weeks) Continuation Phase
Thrice-weekly INH and RIF for 54 doses (18 weeks)
Table reproduced and modified by MoH.

The most current treatment guidelines need to be reviewed and correlated to the patient’s specific condition and circumstances before any treatment is started.

Treatment of drug-resistant and multidrug-resistant tuberculosis TB can be difficult. Patients with these infections are recommended by the CDC to involve infectious-disease specialists as there are multiple approaches that involve other anti-TB drugs and variable treatment schedules that can be used.

In addition, there are new drugs and treatment schedules being developed and approved by the FDA. The infectious-disease consultant may be aware of these newest treatments that may benefit specific patients. For example, bedaquiline (Sirturo) has been approved for treatment of MDR TB, and research with an antimicrobial drug, moxifloxacin, suggests it may help in treatment protocols.

Some side effects of treatment may include the following:
1.Loss of appetite
2.Nausea and/or vomiting
3.Jaundice
4.Paresthesia
5.Bruise formation, bleeding
6.Vision changes
Patients are urged to see their doctor if any side effects occur.

In some patients, the lung destruction may be severe and the only treatment left may be surgical resection of the diseased lung tissue.

Medications are needed for TB treatment. Home remedies will not treat TB but at best may help reduce symptoms. Home remedies may include milk, pineapple, Indian gooseberry, bananas, and many others. Patients should discuss these remedies with their doctors before use.

What types of doctors treat TB?

Although the patient’s primary-care doctor can oversee and coordinate treatment, other specialists like infectious-disease, pulmonary-medicine, internal-medicine, critical-care, and public-health physicians can also be involved in the treatment.

What are complications of tuberculosis?

Although some people may develop no complications, others range from mild to severe complications, including death. Some of the more severe complications include lung function damage, bone pain (spine, ribs, and joints), meningitis, kidney and/or liver malfunction, cardiac tamponade, and visual disturbances.

What is the prognosis of tuberculosis?

For most people who live in areas where diagnosis and treatment is available, the prognosis of TB is good if they complete the treatment protocols. The recurrence rate of TB is low (0%-14%) and some may be due to reinfection. Drug-resistant tuberculosis is more difficult to treat, and the prognosis is not as good. The same poor prognosis occurs for those patients who are immunocompromised, elderly, and in patients with previous infection and treatment for TB.

How can people prevent tuberculosis?

A vaccine against TB is commercially available; it is termed BCG, or Bacille Calmette-Guerin vaccine. However, the vaccine is not recommended for use in the U.S. because of the low risk for TB infections.

Also, the vaccine is highly variable in its ability to prevent adult pulmonary disease. Another problem is that the vaccine may interfere with the interpretation of the tuberculin skin test.

Despite this, a number of countries still use it to reduce childhood infections and miliary disease. Consequently, the CDC makes this recommendation: “The BCG vaccine should be considered only for very select persons who meet specific criteria and in consultation with a TB expert.”

Currently, people who have active TB are suggested to be treated using isolation techniques along with anti-TB drugs to prevent spread according to the CDC. The CDC suggests that patients with probable active TB be isolated in a private room with negative pressure (air exhausted to outside or through a high-efficiency particulate air filter).

Researchers are attempting to produce an effective vaccine; there is a new study involving biobeads that contain several TB bacterial antigens and no live bacteria. The biobeads are being studied and may provide the first new vaccine against TB in 100 years.

The author is a student at Cavendish University Uganda
Public Health.

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